Lowering of elevated conc of uric acid in the plasma. Slow depletion of urate tophi & deposits in the tissues.
Dosage/Direction for Use
GoutAdult 250 mg bd, may be increased by 0.5-g increments every 4 wk. Max: 2 g/day. Probenecid & penicillin therapyAdult 2 g daily in divided doses. Childn 2-14 yr Initially 25 mg/kg body wt. Maintenance: 40 mg/kg body wt/day in 4 divided doses.
Administration
Should be taken with food: Take w/ meals or antacids. Ensure adequate fluid intake.
Contraindications
Blood dyscrasias or uric kidney stones. Childn <2 yr.
Special Precautions
Maintain adequate fluid intake to maintain urine alkalinity. Pregnancy.
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